Computational phenotyping of cognitive decline with retest learning.

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Tác giả: Carol A Derby, Jonathan G Hakun, Mindy J Katz, Sharon H Kim, Richard B Lipton, Zita Oravecz, Nelson A Roque, Martin J Sliwinski, Joachim Vandekerckhove, Cuiling Wang

Ngôn ngữ: eng

Ký hiệu phân loại: 597.8754 *Amphibia (Amphibians)

Thông tin xuất bản: United States : The journals of gerontology. Series B, Psychological sciences and social sciences , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 198597

 OBJECTIVES: Cognitive change is a complex phenomenon encompassing both retest-related performance gains and potential cognitive decline. Disentangling these dynamics is necessary for effective tracking of subtle cognitive change and risk factors for Alzheimer's Disease and Related Dementias (ADRD). METHOD: We applied a computational cognitive model of learning and forgetting to data from Einstein Aging Study (EAS
  n = 316). EAS participants completed multiple bursts of ultra-brief, high-frequency cognitive assessments on smartphones. Analyzing response time data from a measure of visual short-term working memory, the Color Shapes task, and from a measure of processing speed, the Symbol Search task, we extracted several key cognitive markers: short-term intraindividual variability in performance, within-burst retest learning and asymptotic (peak) performance, across-burst change in asymptote and forgetting of retest gains. RESULTS: Asymptotic performance was related to both mild cognitive impairment (MCI) and age, and there was evidence of asymptotic slowing over time. Long-term forgetting, learning rate, and within-person variability uniquely signified MCI, irrespective of age. DISCUSSION: Computational cognitive markers hold promise as sensitive and specific indicators of preclinical cognitive change, aiding risk identification and targeted interventions.
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