Branch Enhanced Photoacoustic Sensor for Comprehensive Sevoflurane Monitoring.

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Tác giả: Huiting Huan, Lixian Liu, Andreas Mandelis, Xiaopeng Shao, Jialiang Sun, Yufeng Yang, Zhifu Yang, Xukun Yin, Yi Zeng, Xueshi Zhang, Xiaoming Zhao

Ngôn ngữ: eng

Ký hiệu phân loại: 606 Organizations

Thông tin xuất bản: United States : ACS sensors , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 1989

 Comprehensive sevoflurane monitoring (CSM, sevoflurane concentrations from parts per billion to percent) is essential for the therapeutic diagnosis of anesthetized patients and occupational exposure monitoring. Photoacoustic spectroscopy, with its advantages of high sensitivity, wide dynamic range, miniaturization, and real-time, holds unique potential for CSM. A highly sensitive resonator with a small volume is an optimal choice regarding the limited exhaled gas amount. Wavelength modulation is not suitable for detecting trace sevoflurane with broad absorption lines because the modulation depth is far from optimal. Sensitive detection can be achieved using chopper-based amplitude modulation
  therefore, a relatively low resonance frequency is critical. By the introduction of flexible polyurethane tubes, a branched photoacoustic cell (BPAC) was developed to compensate for the contradiction between the miniaturized resonator and the low resonance frequency requirement. The resonance frequency of BPAC was as low as 1036 Hz at a compact capacity of only 2.7 mL. Taking advantage of the replaceable and flexible branches, the geometry, resonance frequency, and sensitivity of BPAC could be optimized. The BPAC decoupling of the excitation and absorption paths, therefore, avoided the degradation of thermal-acoustic coupling at high concentrations. The sevoflurane detection results demonstrated that the Branch Enhanced Photoacoustic Spectroscopy (BEPAS) sensor yielded a 1σ limit of detection of 1.61 ppb with a 3 s integration time, corresponding to a normalized noise equivalent absorption coefficient of 2.2 × 10
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