Structure-Based Discovery of a Highly Selective, Oral Polo-Like Kinase 1 Inhibitor with Potent Antileukemic Activity.

• Tác giả: Yan He, Zhongtang Li, Chenzhong Liao, Zhenming Liu, Jianyu Nie, Xiaojiao Sun, Qin Wang, Zhouling Xie, Xinglong Zhang, Mingxin Zhu
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 199143

Tóm tắt

Polo-like kinase 1 (PLK1) plays pivotal roles in cell division and cancer pathogenesis, making it a highly coveted therapeutic target for anticancer strategies. This article reports a series of PLK1 inhibitors developed using a structure-based strategy, culminating in the discovery of compound