Applying electrical stimulation (ES) on nerve or muscle denervation can significantly restore the nerve function and prevent muscle atrophy. The triboelectric nanogenerator (TENG) can couple the mechanical energy and electrical energy for ES. However, the triboelectric performance of fully biodegradable TENGs and the effect of ES need to be optimized and verified. Here, the triboelectric performance of silk fibroin (SF) is regulated by ions to fabricate SF-TENGs with full biodegradability, good biocompatibility, and excellent output. This SF-TENG shows a good electrostimulation recovery effect and is used for function restoration of the injured sciatic nerve and innervated muscle. Li