The prevalence of open lumbar spine procedures has increased due to surgical advancements and an aging population. This study examined prophylactic closure by the plastic and reconstructive surgery (PRS) service compared to similar procedures from the National Surgical Quality Improvement Program (NSQIP) database. Patients who underwent lumbar spine surgery closed primarily by the PRS service at a large academic surgical center between January 2016 and June 2023 were included, while grafts or flaps were excluded. Charts were reviewed for demographics, preoperative risk factors, operative course, superficial surgical site infection (SSI), deep SSI, organ/space SSI, wound dehiscence, seroma, hematoma, cerebrospinal fluid leak, and medical complications. Unplanned readmission and revision surgeries related to the procedure were noted. Outcomes were assessed 30 days postoperatively. Outcomes within 30 days postoperatively were recorded in 46,006 NSQIP cases after matching by Current Procedural Terminology (CPT) and International Classification of Diseases - 10 (ICD-10) codes. A total of 888 consecutive lumbar surgery patients closed by PRS were reviewed. Wound-related revisional surgeries (1.2% vs. 2.6%, p = 0.013) and wound-related readmissions (1.5% vs. 4.2%, p <
0.001) were significantly lower for the PRS group than the NSQIP group. Transfusion (2.7% vs. 4.4%, p = 0.013) and urinary tract infection rates (0.2% vs. 1.3%, p = 0.005) were also lower for the PRS group. PRS closure also showed significantly decreased odds of revisional surgery (ß = 0.587, p = 0.021) and any wound infection (ß = 0.503, p = 0.026) after logistic regression. Thus, PRS closure of lumbar spine procedures may decrease the risk of wound-related revisional surgeries, readmissions, and infections. Therefore, this study supports the use of prophylactic PRS closure in such cases.