INTRODUCTION: Hemoadsorption has emerged as a potential intervention for the removal of ticagrelor. We aimed to evaluate the efficacy of the HA380 hemoadsorption cartridge for this purpose. METHODS: Six healthy adult sheep received 270 mg of ticagrelor via an orogastric tube, followed by hemoadsorption using a HA380 cartridge for a duration of 4 hours. The sorbent-based removal ratio, clearance, and mass removal rate were assessed at multiple time points. RESULTS: The HA380 cartridge achieved an initial sorbent-based removal ratio of 48.9% (SD 11.8) at 10 minutes, which declined rapidly to 2.66% (SD 18.5) at 120 minutes and 0.48% (SD 17.0) at 240 minutes. Clearance followed a similar trend, starting at 46.1 mL/min (SD 11.4) and decreasing to 0.08 mL/min (SD 16.8) at 240 minutes. The mass removal rate also dropped significantly over time, from 3.74 ng/min (SD 2.54) at 10 minutes to near zero at 120 and 240 minutes. CONCLUSION: HA with the HA380 cartridge can achieves an early 50% adsorption level for ticagrelor. If frequently changed, the HA380 cartridge may serve as a potential option for ticagrelor removal, when clinically indicated.