Distinct explanations underlie gene-environment interactions in the UK Biobank.

• Tác giả: Arun Durvasula, Alkes L Price
• Ngôn ngữ: eng
• Ký hiệu phân loại: 920.71 Men
• Thông tin xuất bản: United States : American journal of human genetics , 2025
• Bộ sưu tập: NCBI
• ID: 199746

Tóm tắt

The role of gene-environment (GxE) interaction in disease and complex trait architectures is widely hypothesized but currently unknown. Here, we apply three statistical approaches to quantify and distinguish three different types of GxE interaction for a given trait and environmental (E) variable. First, we detect locus-specific GxE interaction by testing for genetic correlation (r