Vaccination is one of the most important measures for preventing infectious diseases. Vaccinations against tetanus and West-Nile-Virus are essential to protect the individual horse. These infections are not contagious and are not transmitted from animal to animal. By contrast, Equine Influenza and Equine-Herpes-Virus infections are highly contagious, transmissible diseases. In addition to protecting the vaccinated individual, vaccinating as many horses as possible aims at inducing a broad herd immunity, which interrupts infection chains and thus additionally protects the individual. Vaccination against tetanus, Equine Influenza and Equine-Herpes-Virus infections are core vaccinations for horses. The immunization against West-Nile-Virus is currently considered non-core and only recommended in the outbreak areas in eastern parts of Germany and, since 2024, in the entire lowlands of Northern Germany. Prospectively, depending on the future development of the epidemic, vaccination against West-Nile-Virus is likely to become core-component. It will then be recommended for the entire country. In addition to those already mentioned, there are marketing authorizations for vaccines against dermatomycosis, strangles, rotavirus infections, equine viral arteritis and rabies. Depending on the risk of exposure, the use of these vaccines can be highly advisable for individual cases.