Aortic stretch and recoil create wave-pumping effect: the second heart in the systemic circulation.

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Tác giả: Arian Aghilinejad, Coskun Bilgi, Haojie Geng, Niema M Pahlevan

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Journal of the Royal Society, Interface , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 199842

Wave propagation in the heart tube is key to establishing an early pumping mechanism, as explained by impedance pump theory in zebrafish. Though initially proposed for embryonic blood circulation, the role of impedance-like behaviour in the mature cardiovascular system remains unclear. This study focuses on the understudied physiological mechanism of longitudinal displacement in the adult aorta caused by the long-axis motion of the heart. Using magnetic resonance imaging on 159 individuals, we compared aortic displacement profiles between a control group and those with heart failure, revealing a significant difference in aortic stretch between the two groups. Building on this clinical evidence, we conducted
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