BACKGROUND: Most atypical depression (AD) cases endorse prominent mood reactivity, anxiety, and interpersonal sensitivity, resembling some of the characteristics of emotional dysregulation (ED). The present study assesses the frequency and clinical features of different levels of ED in AD METHODS: The present cross-sectional study discriminated depressed outpatients screened with the Hamilton Depression rating scale with the Atypical Depression Supplement (SIGH-ADS), Symptom Checklist-90-Revised, Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire, 110-item version, 36-item Difficulties in Emotion Regulation Scale (DERS), and Young Mania Rating Scale into people with high (ED RESULTS: We included 326 patients (MDD = 204[62.60 %], BD-II = 105[32.20 %], and BD-I = 17[5.20 %]). AD LIMITATIONS: Cross-sectional design
treatment-seeking outpatients. CONCLUSIONS: AD and ED represent intertwined clinical entities potentially relevant to enhanced treatment outcomes, warranting more accurate random-forest models.