Metabolic restoration: Rhubarb polysaccharides as a shield against non-alcoholic fatty liver disease.

• Tác giả: Lin Chen, Xiaobing Dou, Yanyan Gao, Nian Liu, Jiannan Qiu, Huaxin Wei, Fangying Xu, Zhiling Yu, Jinghua Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025
• Bộ sưu tập: NCBI
• ID: 199936

Tóm tắt

Non-alcoholic fatty liver disease (NAFLD) accounts for remarkable burden of death and costs worldwide with no recommended pharmacological intervention for the clinical management. This study aimed to investigate the efficacy and underlying mechanisms of rhubarb-derived polysaccharides (RP) in mitigating high-fat diet (HFD)-induced NAFLD and to analyze the primary monosaccharide components of RP. Forty male C57BL/6 mice were subjected to a dietary intervention consisting of either a high fat or chow diet for a duration of 12 weeks. RP (270, 540 mg·kg