Eucalyptol Attenuates Indomethacin-Induced Gastric Ulcers in Rats by Modulating the ICAM-1, eNOS and COX/LOX Pathways: Insights from In Silico, In Vitro and In Vivo Approaches.

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Tác giả: Athanasios Alexiou, Gaber El-Saber Bathia, Alia Erum, Muhammad Fayyaz-Ur-Rehman, Urooj Iqbal, Mohamed H Mahmoud, Abdul Malik, Malik Hassan Mehmood, Marios Papadakis, Nabeela Tabassum Sial, Ume Ruqia Tulain, Ambreen Malik Uttra, Nermeen N Welson

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 199982

In order to evaluate anti-inflammatory role of eucalyptol (100, 200, and 400 mg/kg orally), inflammation was induced in rats using 0.1 ml of histamine and 0.1 ml of formaldehyde. Furthermore, in vivo gastroprotective potential of eucalyptol (100, 200 and 400 mg/kg) was determined via the intraperitoneal injection of 25 mg/kg indomethacin as an ulcerative agent and omeprazole (30 mg/kg) orally as a standard. Estimation of biochemical (PGE
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