OBJECTIVES: The working-from-home trend aimed at enhancing work-life balance may increase absenteeism due to musculoskeletal disorders (MSDs). This study aims to assess office ergonomic knowledge, estimate the prevalence of MSDs, and identify the risk factors that may increase MSD risk. DESIGN: A cross-sectional design was employed using a valid and reliable questionnaire to attain the objectives. RESULTS: MSDs were prevalent, most commonly affecting the shoulders. The mean ergonomic knowledge score was 3.98 out of nine. According to ROSA, 83% of the workers had a low MSD risk, whereas 16% had a high risk. CONCLUSION: The study revealed the high prevalence of MSDs. Most of the employees had a low MSD risk, and their knowledge of ergonomics was low to moderate. The factors concluded may assist in tailoring the educational program.