Effects of psychological stress on inflammatory bowel disease via affecting the microbiota-gut-brain axis.

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Tác giả: Xiaofen Chen, Yuhan Chen, Mingzhi Hong, Shengjun Huang, Jianzhou Li, Lijuan Li, Suqin Lin, Juan Ma, Lili Ma

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: China : Chinese medical journal , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 200836

Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory condition with chronic and relapsing manifestations and is characterized by a disturbance in the interplay between the intestinal microbiota, the gut, and the brain. The microbiota-gut-brain axis involves interactions among the nervous system, the neuroendocrine system, the gut microbiota, and the host immune system. Increasing published data indicate that psychological stress exacerbates the severity of IBD due to its negative effects on the microbiota-gut-brain axis, including alterations in the stress response of the hypothalamic-pituitary-adrenal (HPA) axis, the balance between the sympathetic nervous system and vagus nerves, the homeostasis of the intestinal flora and metabolites, and normal intestinal immunity and permeability. Although the current evidence is insufficient, psychotropic agents, psychotherapies, and interventions targeting the microbiota-gut-brain axis show the potential to improve symptoms and quality of life in IBD patients. Therefore, further studies that translate recent findings into therapeutic approaches that improve both physical and psychological well-being are needed.
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