Long-read single-cell RNA sequencing enables the study of cancer subclone-specific genotypes and phenotypes in chronic lymphocytic leukemia.

• Tác giả: Gage S Black, Xiaomeng Huang, Gabor T Marth, Philip Moos, Yi Qiao, Deepa Sampath, Deborah M Stephens, Jennifer A Woyach
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.99419 Other diseases
• Thông tin xuất bản: United States : Genome research , 2025
• Bộ sưu tập: NCBI
• ID: 200842

Tóm tắt

Bruton's tyrosine kinase (BTK) inhibitors are effective for the treatment of chronic lymphocytic leukemia (CLL) due to BTK's role in B cell survival and proliferation. Treatment resistance is most commonly caused by the emergence of the hallmark