Genetic abnormalities predict outcomes in patients with core binding factor acute myeloid leukemia.

• Tác giả: Wenbing Duan, Qiang Fu, Lijuan Hu, Xiaojun Huang, Jinsong Jia, Hao Jiang, Qian Jiang, Yueyun Lai, Shengye Lu, Yazhen Qin, Hongxia Shi, Yuqian Sun, Feifei Tang, Jing Wang, Yazhe Wang, Yu Wang, Lanping Xu, Sen Yang, Shunjie Yu, Xiaohui Zhang, Ting Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 324.274709 Political parties
• Thông tin xuất bản: Germany : Annals of hematology , 2025
• Bộ sưu tập: NCBI
• ID: 201127

Tóm tắt

 Research on the comprehensive integration of clinical and genomic characteristics in patients with core binding factor acute myeloid leukemia (CBF-AML) is limited. Clinical and genomic data from consecutive patients with CBF-AML were reviewed. A Cox regression model was used to identify the variables associated with event-free survival (EFS), relapse-free survival (RFS) and overall survival (OS). A total of 346 CBF-AML patients (211 with RUNX1::RUNX1T1 and 135 with CBFB::MYH11) were included in this study. In the RUNX1::RUNX1T1 cohort, multivariate analyses revealed that KDM6A mutations were significantly associated with poor RFS (hazard ratio = 3.1 [1.4, 7.1], p = 0.007) and OS (HR = 11.5 [3.6, 37.0], p <
  0.001)
  FLT3-TKD mutations, poor OS (HR = 4.9 [1.7, 14.3], p = 0.004)
  KIT mutation VAF >
  25%, poor RFS (KIT