Adrenal Cortex: From Physiology to Disease

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Tác giả: Antoine Martinez, Pierre Val

Ngôn ngữ: eng

ISBN-13: 978-2889199198

ISBN: 978-2-88919-919-8

Ký hiệu phân loại: 612.45 Adrenal glands

Thông tin xuất bản: Frontiers Media SA, 2016

Mô tả vật lý: 1 electronic resource (89 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 201203

The adrenal gland plays essential roles in the control of body homeostasis, stress and immune responses. The adrenal cortex represents up to 90% of the gland and is specialised in the production of mineralocorticoids, glucocorticoids and adrenal androgens. This production is tightly coordinated and results from a unique zonal organisation. Although our knowledge of the molecular mechanisms controlling adrenal steroidogenesis is quite extensive, for decades, the mechanisms of adrenal cortex development, cellular homeostasis and renewal have remained elusive. The advent of new high-throughput technologies and sophisticated genetic approaches has brought tremendous progress in our understanding of how the adrenal cortex achieves and maintains its particular organisation. The aim of this Frontiers in Endocrinology Topic is to provide readers with a snapshot of our current knowledge on adrenal physiology and how deregulations of these processes result in adrenal diseases. This includes but is not limited to, basic research on adrenal development, cell lineage identification, progenitor cells, tissue renewal, control of differentiation and zonation and clinical research on the identification of disease-related genes.
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