Cdh23 Gene Mutation-Induced Vestibular Dysfunction in Mice: Abnormal Stereocilia Bundle and Otolith Development and Activation of p53/FoxO Signaling Pathway.

• Tác giả: Ruishuang Geng, Juan Hu, Xiaojing Kuang, Bo Li, Yan Sun, Zehua Sun, Lihuan Tang, Lan Wang, Yuancheng Wu, Daoli Xie, Kai Zhang, Qingyin Zheng, Tihua Zheng
• Ngôn ngữ: eng
• Ký hiệu phân loại: 658.57 Research and development (R and D)
• Thông tin xuất bản: United States : Journal of molecular neuroscience : MN , 2025
• Bộ sưu tập: NCBI
• ID: 201692

Tóm tắt

Vestibular dysfunction (VD) is increasingly acknowledged as a significant contributor to falls and deterioration in health. Cadherin 23 (Cdh23) serves as an essential protein responsible for facilitating the mechanical transduction processes in hair cells, and variations in this gene have been recognized as possible factor to auditory impairments and VD. The gene Cdh23 encodes glycoproteins that play a role in cell adhesion and are crucial for the development of stereocilia bundles. In this research, we generated CDH23 functional null mice (Cdh23