PURPOSE: The complexity of managing ventral hernias leads surgeons to explore different optimal techniques and mesh selection. Hybrid meshes, combining absorbable and permanent components, aim to balance long-term durability and infection risk. This study evaluated the extended-term outcomes of GORE METHODS: Conducted across eight Italian surgery centers from January 2020 to September 2022, this multicenter analysis prospectively assessed the outcomes of patients undergoing laparoscopic repair of incisional hernias using GORE® SYNECOR. Outcomes included postoperative wound events, pain, recurrence, and mesh bulging. RESULTS: A total of 371 patients participated in the study. No serious adverse events or significant mesh-related complications were observed. Surgical site occurrences (SSO) were recorded in a proportion of cases, and hernia sac volume was identified as the only independent risk factor (p <
0.0001). At three months post-surgery, pain levels and impacts on daily activities were minimal. At 24 months, recurrence and mesh bulging were associated only with patients with hernia sac sizes larger than 450 cm CONCLUSION: Laparoscopic incisional hernia repair using GORE CLINICALTRIALS: NCT06166069.