Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis

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Tác giả: Peter Mikus

Ngôn ngữ: eng

ISBN-13: 978-9535106579

Ký hiệu phân loại: 507.2073 Research; statistical methods

Thông tin xuất bản: IntechOpen, 2012

Mô tả vật lý: 1 electronic resource (210 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 201785

 The scientific monograph by the author Peter Mikus entitled ""Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis"" provides a comprehensive view on the advanced capillary electrophoresis techniques aimed to current chiral bioanalysis. The advances in the chiral electrophoresis analytical approaches are divided and theoretically described in three sections involving (i) advanced chiral separations for the optimization of chiral resolution (separation mechanisms
  electrophoresis techniques in capillary and microchip format
  electrophoretic modes such as ITP, CZE/EKC, CEC
  chiral additives / pseudophases / phases), (ii) advanced sample preparation for the on-line preconcentration, sample clean-up and analyte derivatization (implementation of electrophoretic effects such as stacking
  non-electrophoretic effects such as SPE, chromatography, dialysis
  combinations of these effects
  multidimensional CE systems
  instrumental schemes), (iii) advanced combinations of detection and electrophoresis for the optimization in qualitative and quantitative evaluation (the most important universal as well as selective detection approaches such as absorption and fluorescence spectrophotometry, electrochemical detection, mass spectrometry vs. (i) and/or (ii)). Real analytical potential (benefits and limitations) of these advanced analytical approaches is emphasized by selected performance parameters of the methods and illustrated by many current practical applications including chiral analyses of drugs, their (bio)degradation products and biomarkers in pharmaceutical and biological matrices. The author wishes the readers many inspirations in the creation of new innovative approaches in the field of advanced chiral electrophoresis techniques with the aim to overcome capabilities of the current analytical techniques.
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