Comment: 68 pages, 12 figures, 1 Table, 2 annexes, Total of 17,758 wordsDespite its relevance, measuring the contributions of the bioeconomy to national economies remains an arduous task that faces limitations. Part of the difficulty is associated with the lack of a clear and widely accepted concept of the bioeconomy and moves on to the connections between methods, data and indicators. The present study aims to define the concepts of bioeconomy and to explore the connections between concepts, methods, data and indicators when measuring the bioeconomy economically, and the limitations involved in this process. The bioeconomy concepts were defined based on a literature review and a content analysis of 84 documents selected through snowballing procedures to find articles measuring 'how big is the bioeconomy?'. The content of the 84 documents was uploaded to the QDA Miner software and coded according to the bioeconomy concept, the methods or models used, the data sources accessed, the indicators calculated, and the limitations reported by the authors. The results of the occurrence and co-occurrence of the codes were extracted and analyzed statistically, indicating that the measurement of bioeconomy (i) need recognize and pursue the proposed concept of holistic bioeconomy
(ii) rarely considered aspects of holistic bioeconomy (3.5%)
(iii) is primarily based on the concept of biomass-based bioeconomy (BmBB) (94%)
(iv) the association with the concept of biosphere (BsBB) appeared in 26% of the studies
(v) the biotech-based bioeconomy (BtBB) was the least frequent (1.2%)
(vi) there is a diversity of methods and models, but the most common are those traditionally used to measure macroeconomic activities, especially input-output models
(vii) depending on the prevailing methods, the data comes from various official statistical databases, such as national accounts and economic activity classification systems
...