Center frequency as optimal frequency of visual stimulation for spreading entrained gamma rhythms to other target brain regions in cognitively normal older adults.

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Tác giả: Ji Won Han, Hong Jun Kim, Ki Woong Kim, Jaehyeok Park, Yeseung Park, Se Joon Woo, Seunghyup Yoo, Euisuk Yoon

Ngôn ngữ: eng

Ký hiệu phân loại: 912.01 Philosophy and theory

Thông tin xuất bản: Switzerland : GeroScience , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 202025

Gamma entrainment using 40 Hz sensory stimulation has shown promise in AD mouse models, but inconsistent results in AD patients, possibly due to interspecies and interindividual differences in center frequency (CF). This study aimed to investigate whether gamma rhythms entrained by visual stimulation at an individual's CF can spread better than those at other frequency conditions in older adults. We entrained gamma rhythms in 32 cognitively normal older participants using light flickering at 32 Hz, 34 Hz, 36 Hz, 38 Hz, and 40 Hz. We identified each individual's CF among these five frequencies and compared the spread, strength, and stability of gamma connectivity induced by light stimulation flickering at an individual's CF with those at other frequencies using generalized estimating equation and repeated measures ANOVA. In about two-thirds of the participants, 32 Hz (40.6%) and 34 Hz (28.1%) were identified as CF. The mean spread, strength, and stability of gamma connectivity involving the visual cortex (GC
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