Discovery of highly effective antiviral agents based on flavonoid-benzothiazole against TMV.

• Tác giả: Tianyu Deng, Chunmei Hu, Jieyu Li, Da Liu, Xingping Luo, Haotao Pu, Jiao Tian, Wei Xue, Ying Yang, Qing Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 618.0835 Other branches of medicine Gynecology and obstetrics
• Thông tin xuất bản: Netherlands : Molecular diversity , 2025
• Bộ sưu tập: NCBI
• ID: 202043

Tóm tắt

A series of flavonol derivatives containing benzothiazole were designed and synthesized. The structures of all the compounds were characterized by NMR and HRMS. The results of the activity assay showed that some of the target compounds possessed outstanding in vivo antiviral activity against the tobacco mosaic virus (TMV). Among them, the median effective concentration (EC