Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome

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Tác giả: David M. Diamond, Karestan C. Koenen, Tania L. Roth

Ngôn ngữ: eng

ISBN-13: 978-2889194582

ISBN: 978-2-88919-458-2

Ký hiệu phân loại: 616.8521 Diseases of nervous system and mental disorders

Thông tin xuất bản: Frontiers Media SA, 2015

Mô tả vật lý: 1 electronic resource (158 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 202741

 This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans
  epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress
  and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry.
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