Neuroglia Molecular Mechanisms in Psychiatric Disorders

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Tác giả: Alexei Verkhratsky, Caterina Scuderi, Mami Noda

Ngôn ngữ: eng

ISBN-13: 978-2889456987

Ký hiệu phân loại:

Thông tin xuất bản: Frontiers Media SA, 2019

Mô tả vật lý: 1 electronic resource (154 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 202892

 Neuropsychiatric disorders have long been considered as specific dysfunctions of neuronal functions. Studies of the recent decade, however, have challenged this simplistic view, highlighting the important role played by neuroglial cells in the onset and/or progression of neuropsychiatric diseases. In the central nervous system (CNS) non-excitable neuroglia are represented by cells of ectodermal origin (astrocytes, mainly responsible for CNS homeostasis and oligodendrocytes that provide myelination and support for axons) and mesodermal origin (microglial cells that are scions of foetal macrophages entering the neural tube early in development
  these cells provide for CNS defence and contribute to shaping neuronal networks). Pathological changes of neuroglia are complex
  these changes are classified into reactive gliosis (astrogliosis, activation of microglia and hypertrophy of oligodendroglial precursors), gliodegeneration with loss of function and glial pathological remodelling. Combination of these processes defines the evolution of neurological diseases in general and neuropsychiatric disorders in particular. In this research topic we addressed the contribution of neuroglia to major neuropsychiatric pathologies including major depression, schizophrenia, and addictive disorders.
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