OBJECTIVES: Traditional cardiovascular risk (CVR) stratification does not consider CVR enhancers (CVRE). Women present under-recognized CVRE factors that may lead to arterial stiffness (AS). AS is associated with long-term cardiovascular disease. AS can be determined by carotid-femoral pulse wave velocity (cf-PWV). In women with low-CVR and a CVRE, our objective was to determine cf-PWV values and AS, and to compare with a control group. MATERIAL AND METHODS: Multicentric cross-sectional study, from 2022 to 2024 in Argentina. Included women between 18 and 59 years-old, without traditional CVR-factors, low (<
5 %) 10-year CVR, and office blood-pressure (BP) <
140/90 mmHg. Inclusion criteria: Group 1: presence of a CVRE (history of gestational hypertension, preeclampsia
autoimmune rheumatic or hematological disease in clinical remission
previous oncological treatment in current complete remission
history of abortions
early menopause or menarche
anxiety or depression disorder
human immunodeficiency virus infected virally suppressed). Group-2: women who attended routine control. Exclusion criteria: hypertension
diabetes
target organ damage
chronic kidney disease
current smoking
history of CV-event
statins, aspirin, or antihypertensive treatment. RESULTS: Included 280 women: Group-1 (N = 174)
Group-2 (N = 106). Group-1 showed higher cf-PWV: 7.02±1.20 vs. 5.71±0.86 ( CONCLUSIONS: Women with CVRE showed greater cf-PWV and higher frequency of AS.