Enhanced immunogenicity of a Clostridioides difficile TcdB vaccine adjuvanted with a synthetic dual-TLR ligand adjuvant.

• Tác giả: Mayuresh M Abhyankar, G Brett Moreau, Christopher B Fox, Nicholas Hagspiel, Joel Herbein, Farha Naz, William A Petri, Brandon Thompson, Feifan Xu, Mary Young
• Ngôn ngữ: eng
• Ký hiệu phân loại: 920.71 Men
• Thông tin xuất bản: England : NPJ vaccines , 2025
• Bộ sưu tập: NCBI
• ID: 203404

Tóm tắt

We report a comprehensive evaluation of the toxin B (TcdB) vaccine adjuvanted with a dual Toll-like receptor ligand liposome adjuvant for Clostridioides difficile infection (CDI). The vaccine completely protected mice from a lethal infection. Compared to alum adjuvanted TcdB, it generated functionally superior systemic antibodies and supported strong memory B cell and gut IgA responses. This pharmaceutically acceptable adjuvant platform holds promise for developing a next-generation CDI vaccine.