Accurate prediction of air quality time series data is helpful to identify and warn air pollution events in advance. Although the current air quality prediction models have made some progress in improving the accuracy of prediction, due to the impact of specific pollutants or complex meteorological conditions, these models still have the problems of low prediction accuracy, robustness and generalization ability in univariate prediction. In order to solve these problems, this study proposes a framework that integrates D-S evidence theory and a variety of deep learning models. The air quality data of three representative cities with climate characteristics in China are obtained and five indicators on air pollutants are collected. The preprocessed data are divided by time length to form short-term, medium-term and long-term input data, and MLP, RNN, CNN, LSTM, BI-LSTM and GRU models are established respectively. By comparing the performance indicators of the six models, three most suitable models are selected to predict the short, medium and long-term data respectively. Taking the prediction results and reliability as the three evidence bodies of the theory, a fusion model based on D-S evidence theory is established. For the three performance indicators MAE, RMSE and MAPE of the model, the best result of the fusion model increases the performance by 7.42%, 4.25% and 12.82% compared with the sub optimal architecture. This shows that integrating D-S evidence theory and a variety of deep learning algorithms provides an effective method to accurately predict the long-term air quality level in most urban areas.