Mechanisms of Innate Neuroprotection

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Tác giả: Giuseppe Pignataro

Ngôn ngữ: eng

ISBN-13: 978-2889199297

Ký hiệu phân loại:

Thông tin xuất bản: Frontiers Media SA, 2016

Mô tả vật lý: 1 electronic resource (138 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 203951

As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans.
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