Long-lasting sex-specific alteration in left ventricular cardiac transcriptome following gamma and simGCRsim radiation.

• Tác giả: Arsen Arakelyan, Malik Bisserier, Agnieszka Brojakowska, Suren Davitavyan, Venkata Naga Srikanth Garikipati, David A Goukassian, Lahouaria Hadri, Siras Hakobyan, Gisane Khachatryan, Mary K Khlgatian, Susmita Sahoo, Tamara Sirunyan, Ani Stepanyan, Roksana Zakharyan, Shihong Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 597.9598 Reptilia (Reptiles)
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 204693

Tóm tắt

Space irradiation (IR) is an important health risk for deep-space missions. We reported heart failure with preserved ejection fraction like cardiac phenotype 660-days following exposure to a single-dose of a simplified galactic cosmic ray simulation (simGCRsim) only in males with functional and structural impairment in left ventricular (LV) function. This sex-based dichotomy prompted us to investigate sex-specific changes in the LV transcriptome in three-month-old male and female mice exposed to