Associations of mucinous differentiation and mucin expression with immune cell infiltration and prognosis in colorectal adenocarcinoma.

• Tác giả: Maarit Ahtiainen, Ville K Äijälä, Jan Böhm, Hanna Elomaa, Olli Helminen, Henna Karjalainen, Meeri Kastinen, Markus J Mäkinen, Jukka-Pekka Mecklin, Sanna Meriläinen, Tero Rautio, Jukka Rintala, Juha Saarnio, Toni T Seppälä, Onni Sirkiä, Päivi Sirniö, Vilja V Tapiainen, Vilma Tarkiainen, Anne Tuomisto, Juha P Väyrynen, Erkki-Ville Wirta
• Ngôn ngữ: eng
• Ký hiệu phân loại: 617.715 Diagnosis and prognosis
• Thông tin xuất bản: England : British journal of cancer , 2025
• Bộ sưu tập: NCBI
• ID: 204786

Tóm tắt

 BACKGROUND: The production of extracellular mucus and expression of mucins are commonly aberrant in colorectal cancer, yet their roles in tumour progression remain unclear. METHODS: To investigate the potential influence of mucus on immune response and prognosis, we analysed mucinous differentiation (non-mucinous, 0%
  mucinous component, 1-50%
  mucinous, >
 50%) and its associations with immune cell densities (determined with three multiplex immunohistochemistry assays or conventional immunohistochemistry) and survival in 1049 colorectal cancer patients and a validation cohort of 771 patients. We also assessed expression patterns of transmembrane (MUC1, MUC4) and secreted (MUC2, MUC5AC and MUC6) mucins using immunohistochemistry. RESULTS: Mucinous differentiation was associated with higher densities of CD14 CONCLUSIONS: Although mucinous differentiation did not independently predict survival, extracellular mucus and MUC1 expression could promote tumour progression through immunosuppression.