Topics on Drug Metabolism

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Tác giả: James Paxton

Ngôn ngữ: eng

ISBN-13: 978-9535100997

Ký hiệu phân loại:

Thông tin xuất bản: IntechOpen, 2012

Mô tả vật lý: 1 electronic resource (308 p.)

Bộ sưu tập: Tài liệu truy cập mở

ID: 205186

 In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability
  the influence of genetic and epigenetic factors on drug metabolism
  impact of disease on transport and metabolism
  and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.
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