Old age odor is associated with delayed skin renewal and fatty acid oxidation by skin bacteria, potentially causing discomfort and health issues. While previous studies primarily targeted 2-nonenal inhibition, this study examined the antibacterial, antioxidant, biofilm inhibition, SDS-PAGE analysis, and trans-2-nonenal scavenging effects of Leuconostoc mesenteroides THF-10, a lactic acid bacterium isolated from Cucumis melo. The cell-free supernatant inhibited