BACKGROUND: The effectiveness of Kinesio Taping (KT) for mild-to-moderate Carpal Tunnel Syndrome (CTS) remains controversial. OBJECTIVE: To evaluate both the short-term and long-term efficacy of KT in the management of CTS. METHODS: Electronic searches were conducted in PubMed, EMBASE, The Cochrane Library, Web of Science and Scopus databases up to October 2024. Randomized controlled trials comparing KT with control (sham, no intervention, or basic treatment) or other conservative treatment were included. The revised Cochrane Risk of Bias tool (ROB-2) was used to assess the risk of bias across studies. Meta-analysis was performed to pool data from studies, calculating Mean Differences (MD) and 95% confidence intervals (CI) for continuous outcomes. RESULTS: Fourteen studies with 637 participants were included. Kinesio Taping (KT) significantly improved long-term pain relief compared to control (MD = -1.14, 95% CI: -1.69 to -0.59, CONCLUSION: Low to moderate quality evidence indicates that KT may effectively improve long-term pain relief and functional outcomes in patients with CTS. Additionally, low quality evidence suggests that the combination of KT and orthoses may provide greater short-term pain relief.