Eugenia involucrata is an underexplored indigenous plant species found in the southern and southeastern regions of Brazil. Recent investigations have disclosed the substantial presence of bioactive phenolic compounds (PC) in various plant parts (leaves, pulp, and seeds) of this species. This study aimed to assess the in vitro anti-hyperglycemic, anti-obesogenic, and antioxidant potential of PC extracts derived from the fruit pulp and seeds of E. involucrata. This evaluation encompassed their capacity to inhibit enzymes involved in carbohydrate and lipid digestion, as well as the formation of advanced glycation end products (AGEs). Additionally, the study examined their ability to neutralize biologically relevant reactive species. The extraction yield of PC was 26-fold higher for seed over pulp extracts. Pulp extract had lower values of inhibitory concentration 50% (IC