USP9X suppresses ferroptosis in diabetic kidney disease by deubiquitinating Nrf2

• Tác giả: Kedan Cai, Yue Hong, Qun Luo, Ningjun Shao, Lingping Wu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 636.0885 Animal husbandry
• Thông tin xuất bản: England : Renal failure , 2025
• Bộ sưu tập: NCBI
• ID: 208659

Tóm tắt

Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates many critical genes associated with iron storage and transportation, the activity of which is influenced by E3 ligase-mediated ubiquitination. We wondered whether there is a deubiquitinase that mediates the deubiquitination of Nrf2 to stabilize Nrf2 expression and further prevent diabetic kidney disease (DKD). High glucose (HG) was applied to induce an