The Effects of the Early and Late Phases of Septic Shock on the Population Pharmacokinetics of Vancomycin.

• Tác giả: Apinya Boonpeng, Kessarin Chaisiri, Jutamas Dechsanga, Tanisa Lexnoi, Wichai Santimaleeworagun, Sirima Sitaruno, Chutchawan Ungthammakhun, Veerapong Vattanavanit
• Ngôn ngữ: eng
• Ký hiệu phân loại: 700.105 Effects of science and technology on the arts
• Thông tin xuất bản: England : Journal of clinical pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 208740

Tóm tắt

Pathophysiologic changes in the early and late phases of septic shock affect the pharmacokinetic (PK) parameters, varying dose adjustments may be necessary. This study aimed to create the PK models of vancomycin in the early and late phases of septic shock and to describe the association between the area under the curve from 0 to 24 h (AUC