A Pharmacophore for Drugs Targeting the α4α4 Binding Site of the (α4)

• Tác giả: Thomas Balle, Ali S Kusay, Yujia Luo, Megan L O'Mara
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Journal of neurochemistry , 2025
• Bộ sưu tập: NCBI
• ID: 208768

Tóm tắt

 Neuronal nicotinic acetylcholine receptors (nAChRs) have an established role in pain pathways and devastating neurodegenerative diseases
  however, few drugs have been successfully developed to target them. The most abundant nAChR in the brain, the α4β2 nAChR, is assembled from five subunits in a 3α:2β stoichiometry-(α4)