Lip augmentation (LA) procedures can cause complications such as edema, erythema, and pain. Photobiomodulation therapy (PBMT) has been indicated as a promissory alternative therapy. We evaluated different PBMT protocols on the management of its complications. Sixty-one patients post-LA were divided into four groups: control
PBMT λ660 nm
PBMT λ808 nm
and PBMT λ660 and 808 nm simultaneously. A higher analgesia was observed in the PBMT λ660 nm group. Upper-lip edema only decreased in the PBMT λ808 nm. Erythema increased in the control, whereas the PBMT groups had smaller score variations. PBMT emitting 660 or 808 nm was efficient for the treatment of edema and erythema post-LA.