A Microneedle Patch Delivers Mitochondria- and Lysosomes- Dual Targeting Prodrug-Like Photosensitizers with Regulated Photoactivity for Precise Photodynamic Therapy.

• Tác giả: Zheng Liu, Li Ren, Zhimin Tang, Miaojian Wan, Ying Yin, Jiezhao Zhan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 571.657 +Mitochondria
• Thông tin xuất bản: Germany : Advanced healthcare materials , 2025
• Bộ sưu tập: NCBI
• ID: 208877

Tóm tắt

Antitumor photodynamic therapy (PDT) faces huge challenges as selectivity and phototoxic damage, requiring delivery photosensitizers (PSs) to specifically accumulate in tumors even in organelle, and avoid the phototoxic damage during delivery. Herein, a microneedle patch (AIE-mito-TPP@MN) containing mitochondria- and lysosomes- dual targeting prodrug-like PSs (AIE-mito-TPP/AlPcSNa