Recently wearable breath sensors have received significant attention in personalized healthcare systems by offering new methods for remote, non-invasive, and continuous monitoring of various health indicators from breath samples without disrupting daily routines. The rising demand for rapid, personalized diagnostics has sparked concerns over electronic waste from short-lived silicon-based devices. To address this issue, the development of flexible and wearable sensors for breath sensing applications is a promising approach. Research highlights the development of different flexible, wearable sensors operating with different operating principles, such as chemiresistive sensors to detect specific target analytes due to their simple design, high sensitivity, selectivity, and reliability. Further, focusing on the non-invasive detection of biomarkers through exhaled breath, chemiresistive wearable sensors offer a comprehensive and environmentally friendly solution. This article presents a comprehensive discussion of the recent advancement in chemiresistive wearable breath sensors for the non-invasive detection of breath biomarkers. The article further emphasizes the intricate development and functioning of the sensor, including the selection criteria for both the flexible substrate and advanced functional materials, including their sensing mechanisms. The review then explores the potential applications of wearable gas sensing systems with specific disease detection, with modern challenges associated with non-invasive breath sensors.