Cellular War: The Dominance Struggle of Polycythemia Vera and Chronic Lymphocytic Leukemia Clones Within a Patient.

• Tác giả: Sena U Coskuner, Firdevs P Eskin, Gozde Ilhan, Erdal Kurtoglu, Pusem Patir, Dinc Suren, Sinem E P Unal
• Ngôn ngữ: eng
• Ký hiệu phân loại: 306.47 *Art
• Thông tin xuất bản: Germany : Clinical laboratory , 2025
• Bộ sưu tập: NCBI
• ID: 209105

Tóm tắt

BACKGROUND: Polycythemia vera (PV) and chronic lymphocytic leukemia (CLL) are distinct hematological malignancies. While their coexistence is rare, it poses unique diagnostic and therapeutic challenges. METHODS: A 50-year-old male patient presented with elevated hemoglobin levels and a marked lymphocytosis. Diagnostic investigations revealed the presence of both PV and CLL. The patient received treatment for PV followed by CLL. RESULTS: Initial treatment with hydroxyurea for PV led to progression of CLL. Subsequent treatment with rituximab and venetoclax effectively managed CLL, although the JAK2V617F mutation re-emerged. CONCLUSIONS: This case highlights the potential for independent origins of myeloid and lymphoid neoplasms. Further research is needed to understand the interplay between these two malignancies and optimize their management.