Potential of Histone Deacetylase 6 Inhibitors as a Treatment of Neurodegenerative Diseases.

• Tác giả: Ahmed F Abdel-Magid
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.4582 Astronautics
• Thông tin xuất bản: United States : ACS medicinal chemistry letters , 2025
• Bộ sưu tập: NCBI
• ID: 209674

Tóm tắt

The invention in this patent application relates to 2-substituted-6-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)isoindolin-1-one derivatives represented herein by formula 1. These compounds possess HDAC6 inhibitory activity and may be useful for the treatment of central nervous system diseases including neurodegenerative diseases such as Alzheimer's disease and progressive supranuclear palsy.