Stimulation of TRPV1+ peripheral somatosensory nerves suppress inflammation via the somato-autonomic reflex.

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Tác giả: Cheng Cao, Zheng Cao, Yong Hu, Zijing Liu, Fengyu Mao, Dengcen Song

Ngôn ngữ: eng

Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a

Thông tin xuất bản: United States : iScience , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 210295

Excessive inflammation causes a wide range of diseases. Here, we found that stimulating TRPV1+ nerves at the nape activated the nucleus of the solitary tract and C1 neurons in the brainstem via the somatosensory afferent pathway, and rapidly induced the secretion of corticosterone, and drove the vagal-adrenal axis to release serum catecholamines, and activated the autonomic-splenic reflex to suppress cytokine production. RNA sequencing (RNA-seq) analysis revealed that stimulating TRPV1+ nerves significantly changed the expression of genes enriched in multiple pathways related to the inflammatory response in the spleen under pathological and normal physiological conditions. TRPV1 agonist lost these anti-inflammatory effects in
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