Skullcapflavone II suppresses TGF-β-induced corneal epithelial mesenchymal transition

• Tác giả: Yu-Fei Dang, Li Li, Meng-Xi Li, Yu-Fan Li, Yang-Yang Yue, Yue Zhang, Zhen Zhang, Fan-Ru Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 331.124 Job vacancies (Job openings)
• Thông tin xuất bản: China : International journal of ophthalmology , 2025
• Bộ sưu tập: NCBI
• ID: 210711
• Chủ đề: 1. Skullcapflavone; 2. Ii; 3. Suppresses

Tóm tắt

AIM: To investigate the effect of skullcapflavone II (SCF-II) on the epithelial-mesenchymal transition (EMT) induced by transforming growth factor beta (TGF-β) in human corneal epithelial cells (HCECs), as well as to identify the signaling pathways that may be involved. METHODS: HCECs were cultured RESULTS: Treatment with SCF-II decreased HCEC viability in a dose-dependent manner. A concentration below 10 µmol/L did not present obvious cell toxicity, and survival rates were more than 70% at 48h. Treatment with SCF-II (5 and 10 µmol/L) significantly impeded migration in wound healing and Transwell migration assays ( CONCLUSION: SCF-II inhibit TGF-β-induced EMT in HCECs by potentially regulating the NF-κB signalling pathway. Thus, SCF-II represents a candidate putative therapeutic agent in corneal fibrotic diseases.