Identification and exploration of anticancer activity of novel peptides isolated from the edible bivalve

• Tác giả: Ehab El-Dabaa, Mohamed ElZallat, Samah I Ghoname, Mohamed R Habib, Olfat A Hammam, Ahmed A A Hussein, Hend Okasha, Maha B Salem
• Ngôn ngữ: eng
• Ký hiệu phân loại: 272.3 Persecutions of Waldenses and Albigenses
• Thông tin xuất bản: Ireland : Toxicology reports , 2025
• Bộ sưu tập: NCBI
• ID: 211047

Tóm tắt

BACKGROUND: The requirement for relevant and safe drugs for cancer treatment is considered a challenge. Recently, marine isolated compounds with various therapeutic targets have attracted many researchers. AIM: Isolation and identification of potential anticancer peptides from edible RESULTS: Five different fractions were purified according to ionic charges and two fractions (4 and 5) showed a potent anticancer activity with a total anticancer score threshold of ≥ 0.5, and hydrophilicity mean of 1.75 that related to stability and solubility. The apoptotic and autophagy-related markers were significantly up-regulated in both HepG2 and HT-29 cells treated with IC CONCLUSION: Natural source peptides derived from the soft tissue of