Folate-Functionalized CS/rGO/NiO Nanocomposites as a Multifunctional Drug Carrier with Anti-Microbial, Target-Specific, and Stimuli-Responsive Capacities.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Arumugam Ayyakannu, Gopinath Kasi, Wing-Fu Lai, Sreekanth Reddy Obireddy, Badrinathan Sridharan, Karthika Viswanathan

Ngôn ngữ: eng

Ký hiệu phân loại: 271.6 *Passionists and Redemptorists

Thông tin xuất bản: New Zealand : International journal of nanomedicine , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 211061

PURPOSE: This study reports the synthesis of surface-modified chitosan (CS) coated with reduced graphene oxide/nickel oxide (rGO/NiO) as a multifunctional drug carrier with anti-microbial, target-specific, and stimuli-responsive capacities. CS, rGO, and NiO nanoparticles are selected due to their pH-responsiveness, large surface area, and ROS generating-capacity, respectively. METHODS: The CS/rGO/NiO nanocomposites (NCs) are synthesized using a solvothermal approach. Glutaraldehyde is used to crosslink CS and rGO/NiO to enhance the stability of the NCs. Structural properties, magnetic properties, antimicrobial activity, drug release sustainability and toxicity of the NCs are evaluated. RESULTS: The NCs show good biocompatibility, excellent magnetic properties, good target specificity, and remarkable cell growth inhibitory effects. The release of doxorubicin (DOX) from the drug-loaded NCs at pH 5.0 (~98.6%) is much higher than that at pH 7.4 (~9.6%). Furthermore, the NCs inhibit the growth of A549 and MCF7 cells, causing the viability of A549 and MCF7 to drop to 12.3% and 7.1%, respectively. By using zebrafish embryos as a model, no detectable change is observed in the survival rate of the embryos after NC treatment. CONCLUSION: The NCs exhibit multifunctional, target-specific, and pH-responsive characteristics. These properties make the NCs a promising candidate for use in drug delivery applications.
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH