OBJECTIVES: A monoterpene alpha-pinene possesses anti-oxidant, anti-inflammatory, and anti-apoptotic properties. Here, we investigated the effect of alpha-pinene on molecular, biochemical, and histological changes induced by carbon tetrachloride (CCl MATERIALS AND METHODS: Animals were divided into four groups: Control, Pinene, CCl RESULTS: The results revealed that alpha-pinene inhibited enhancing liver enzyme AST ( CONCLUSION: We concluded that alpha-pinene reduced CCl