Predicted indirectly recognizable HLA epitopes scores and clinical outcomes after haploidentical stem cell transplantation in pediatric patients with relapsed neuroblastoma.

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Hee Won Cho, Won Young Heo, Ju Kyung Hyun, In Hwa Jeong, Hee Young Ju, Eun-Suk Kang, Ji Won Lee, Eun Seop Seo, Ki Woong Sung, Keon Hee Yoo

Ngôn ngữ: eng

Ký hiệu phân loại: 297.1248 Sources of Islam

Thông tin xuất bản: Switzerland : Frontiers in immunology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 212173

Thêm vào giỏ Liên kết toàn văn

INTRODUCTION: The Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) model is a recently developed algorithm that predicts indirect T-cell recognition by calculating the number of such epitopes in donor-recipient pairs. METHODS: In this study, the clinical significance of PIRCHE was evaluated in pediatric patients with relapsed/progressed neuroblastoma undergoing haploidentical stem cell transplantation (haplo-SCT). RESULTS: A higher PIRCHE-I score was associated with faster platelet recovery ( CONCLUSION: In conclusion, higher PIRCHE-I and PIRCHE-II scores are linked to better survival outcomes and reduced complications in pediatric haplo-SCT neuroblastoma patients. Incorporating PIRCHE scores into donor selection is expected to optimize transplant outcomes.

Tạo bộ sưu tập với mã QR