BACKGROUND: Systemic lupus erythematosus (SLE) is a complex autoimmune disease requiring interprofessional collaborative care because of its varied manifestations. This study explores the experiences of individuals living with SLE regarding the communication and collaboration among their healthcare providers. OBJECTIVES: This study aimed to explore the communication dynamics that shape treatment experiences and well-being in SLE care. METHOD: A qualitative multiple case study design was used, with thematic analysis of semi-structured interviews from six people living with SLE. RESULTS: Three primary themes emerged: the necessity of cohesive healthcare teams, the centrality of client-centred care and the significant challenges posed by fragmented healthcare systems. CONCLUSION: The study highlights the need for integrated care models to enhance communication and coordination among healthcare providers. CONTRIBUTION: This research adds empirical insights into the communication dynamics within medical teams managing SLE, advocating for client-centred and systemic improvements in care coordination.